*Sulfasalazine* #Formulations : Tablet #Brand_Names : Salazopyrin #Pharmacological_Action : It composed of sulfapyridine and 5amino salicylic acid. Sulfapyridine split off in the colon by bacterial action and absorbed systematically appears to be the active moiety. #Side_Effects : Hepatitis #Dose : 1- 3 g/day TDS #Therapeutic_Uses : used as antirheumatoid drug.
Sulfasalazine: Tablet
*Hydroxychloroquine* #Formulations : Tablet. #Brand_Names : Zhquine, ZYQ, HCQS #Pharmacological_Action : It reduces monocyte interleukin I , consequently inhibiting B lymphocytes. Antigen processing may be interfered with Lysosomal stabilization and free radical scavenging are the other proposed mechanism. #Dose : 400 mg/day for 4-6 weeks followed by 200 mg/day for maintenance. #Therapeutic_Uses : used as antirheumatoid drug.
Hydroxychloroquine: Tablet
*Leflunomide* #Formulations : Tablet #Brand_Names : Lefra #Pharmacological_Action : It rapidly converted in the body to an active metabolite which inhibits dihydroorate dehydrogenase and pyrimidine synthesis in actively dividing cells. Antibody production in B cells may be depressed. #Dose : 100mg/day for 3 days followed by 20mg OD. #Therapeutic_Uses : used as antirheumatoid drug.
Leflunomide: Tablet
*Tofacitinib* #Formulations : Tablet #Brand_Names : Xeljang #Pharmacological_Action : It inhibits JAK - STAT signing pathway and DNA transcription. Production of inflammatory mediators and release of cytokines is inhibited. #Side_Effects : Headache, Insomnia, Diarrhoea, Hypertension, Anaemia #Dose : 5mg BD #Therapeutic_Uses : used as antirheumatoid drug.
Tofacitinib: Tablet
*Etanercept* #Formulations : Injection #Brand_Names : Enbrel, Enbrol #Pharmacological_Action : Recombinant fusion protein of TNF receptor with flucytosin portion of human immunoglobulin. #Dose : 25- 50 mg #Therapeutic_Uses : used as antirheumatoid drug.
Etanercept: Injection
*Infliximab* #Formulations : Tablet, Injection #Brand_Names : NA #Pharmacological_Action : Binds and neutralize TNF. #Side_Effects : Fever, Chills, Urticaria, Bronchospasm #Dose : 3- 5mg/kg #Therapeutic_Uses : used as antirheumatoid drug.
Infliximab: Tablet, Injection
*Adalimumab* #Formulations : Tablet, Injection #Pharmacological_Action : same as Etanercept. #Dose : subcutaneous 40mg #Therapeutic_Uses : used as antirheumatoid drug.
Adalimumab: Tablet, Injection
*Anakinra* #Formulations : Tablet, Injection #Pharmacological_Action : It is a recombinant human interleukin I receptor antagonist. #Dose : 100 mg subcutaneous daily. #Therapeutic_Uses : used as antirheumatoid drug.
Anakinra: Tablet, Injection
*Rituximab* #Formulations : Tablet, Injection #Pharmacological_Action : This chimerized monoclonal antibody depletes B lymphocytes and is indicated in B cell lymphoma. #Therapeutic_Uses : used as antirheumatoid drug.
Rituximab: Tablet, Injection
