*Chlorpromazine Hydrochloride* #Formulations : Chlorpromazine tablet Chlorpromazine injection Chlorpromazine elixir Chlorpromazine suppositories #Brand_Names : Largactil, Megatil, Sunprazin, Chlorozine, Clozine, Talentil - T, Talentil Forte #Pharmacological_Action : It produces its antipsychotic effect by the post synaptic blockade at the D2 receptors in the mesolimbic pathway. However, the blocking of D2 receptors in the nigrostriatal pathway is responsible for its extrapyramidal side effects. The antiemetic effect of chlorpromazine stems from the combined blockade of Histamine H1, dopamine D2, and muscarinic M1 receptors in the vomiting centre. It is extensively metabolised by the liver. It also undergoes metabolism in the kidney and GI tract. It is excreted in the urine, bile, and feces. It has a half life of between 23 and 37 hours for the parent drug, and its active metabolite has a half life of 10 to 40 hours. #Side_Effects : dry mouth, dizziness, urine retention, blurred vision, constipation #Therapeutic_Uses : used as antipsychotic drugs.
Chlorpromazine Hydrochloride: Tablet, Injection
*Haloperidol* #Formulations : Tablet, Injection, Oral Liquid, Drops #Brand_Names : Serenace, Senorm, Halopidol #Pharmacological_Action : It has high potency and pharmacological profile resembling that of piperazine substitute phenothiazines. It is not selective for D2 receptors. It is metabolised by CYP3A4 and 2D6 both. Elimination t½ averages 24 hours. #Dose : 1- 10 mg BD #Therapeutic_Uses : used as antipsychotic Drugs.
Haloperidol: Tablet, Injection
